Currently there is no cure for Alzheimers. Only 3 drugs out of 106 possibles have made it to the market since 1998.....a market failure? Perhaps one day
there will be a cure. Dementia is the biggest health and social care challenge of our generation, but
research into the condition has been chronically underfunded. This lack of funding has hampered progress and also restricted the number of scientists and clinicians
working in the dementia field.The brain is an extremely complex organ and for that reason any drug research is
extremely expensive and there are many drugs abandoned in the early stages. Partly because of this, the current emphasis is mainly on prevention and an understanding
of the causes of dementia and Alzheimer's. Lifestyle is important in the way we treat our bodies. Alcohol and drug abuse in the young may be a big dementia problem
coming down the road in the years ahead.
Supporting documentation for Research and Drugs, Health Foods and Alternatives, a List of Nootropics and Lifestyle and Risks Factors relative to this page
can be found in our supporting website www.dementiafacts.co.uk
Drugs, Lifestyle and Risks
You need to utilize the best available evidence today to avert Alzheimer's disease a couple of decades ahead in your future. That is what the best authorities are saying today.
The changes in the brain associated with early Alzheimer's memory loss begin at least two decades prior to noticeable mental decline. Treatment when symptoms first begin to arise
may be too late to reverse deleterious effects upon the brain, but preferably, it would be more productive to develop a treatment that will be prescribed in the earliest
stages of mental decline. By the year 2040 there may be as many as 80 million sufferes on the planet, adults who have lost their memory, ability to communicate, make judgments and live
independently. Recognizing humanity is running out of time, and that the lengthening lifespans across the globe will surely increase the incidence of Alzheimer's dementia, drug companies
and Governments have stepped up their research and development programs. Whilst there are masses of research studies on Alzheimer's in the literature, sadly so far, we don't have a result.
When I first started this website, I did not originally intend to look at medication etc., but by reading the general literature on the
inevitability of Alzheimer's, I found I needed to
understand whether there was any hope of a way out. It seems to the layman that there are probably 4 avenues to consider;
a) Immunisation in middle age well in advance of 'old age'.
b) Vaccination when the symptoms of MCI first appear.
c) A drug to halt the decline once Alzheimer's kicks in.
d) Lifestyle patterns or changes to lower the risk early enough in life.
The obvious problem with drugs and vaccines is of course the development timescales to bring such things to market. There is clearly no shortage of volunteers for human trials but the
complexity of the human brain makes it highly unlikely that there will be a simple solution. It will take time, and if you are approaching later life, your best bet at the moment is to adopt
a healthy diet and lifestyle and keep your fingers crossed.
Nootropics are a class of nutrients, supplements, and nutraceuticals that are observed to improve brain performance and health. They may increase memory, learning,
reasoning, intelligence, cognitive processing speed, verbal fluidity, attention, focus, motivation, mood and energy. They work in a variety of different ways, though many share similar
mechanisms of action. Some increase the supply of neurtransmitters and other neurochemicals that are involved in intra- and inter-neuron communication as well as brain signalling pathways
related to cognition, memory formation and recall. Some may enhance brain activity by modulating neuroreceptors, increasing the uptake of oxygen, glucose and other nutrients into brain
cells or by promoting the underlying health of brain systems. Still other nootropics have been shown to stimulate the development of new neurons and synapses, increasing the overall plasticity
of the brain. The phrase “nootropic” was coined by a Dr.C.E. Giurgea. The term itself is of Greek origin, coming from the word “nous” which means “mind” and the root “tropo-” which translates into “turning”
or “change”. Giurgea laid out a strict set of definitions for the class, requiring that they must enhance learning
and memory, exhibit neuroprotective effects and show extremely low toxicity with minimal side effects. Today, Nootropics are used by a broad range of society and for a broad range of purposes from
improving academic performance to supporting healthy brain function and preventing cognitive diseases such as Alzheimer’s. Some of these have already been mentioned.